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BCR-ABL1 fusion transcripts detected below the limit of quantitation. BCR-ABL1 to ABL1 ratio cannot be calculated. IS result <0.0069%. Not detected.
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Brown et. al. Blood Cancer J. 2011;1(3):e13. doi: 10.1038/bcj.2011.10. Epub 2011 Mar 25 Measurement of BCR-ABL1 Expression on the International Scale Justin T. Brown 1 , Benjamin Hanfstein 2 , Philipp Erben 2 , Katrin Ackermann , Martin C. Müller 1Asuragen, Inc., Austin, Texas, USA, 2 Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Germany Sensitivity of this assay may be limited, and sequencing may not be possible in patient samples containing low tumor burden (ie, low levels of BCR-ABL1 fusion transcript by international scale % or normalized copy number) Not intended to be used for detection or quantification of BCR-ABL1 fusion transcripts Establishment of a standardized multiplex assay with the analytical performance required for quantitative measurement of BCR–ABL1 on the international reporting scale Major BCR-ABL1 mRNA in patients with chronic myeloid leukemia (CML) has generally been analysed by real-time polymerase chain reaction (PCR).
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ipsogen BCR-ABL1 Mbcr RGQ RT-PCR Kit Handbook - QIAGEN
for detecting major BCR-ABL1 mRNA on an International Scale Chikashi Yoshida 1*, Hirohisa Nakamae2, Linda Fletcher3, Daisuke Koga4, Takayuki Sogabe 4, Itaru Matsumura5, Yuzuru Kanakura6, Susan Branford3,7,8,9 and Tomoki Naoe10 Abstract Background: Detection and quantitation of BCR-ABL1 transcripts are crucial for managing patients with chronic Establishment of a standardized multiplex assay with the analytical performance required for quantitative measurement of BCR-ABL1 on the international reporting scale. Brown et. al. Blood Cancer J. 2011;1(3):e13.
Jan 15, 2014 The development of the International Scale for BCR–ABL1 RQ-PCR assessment has enabled quantification of molecular response in relation
Nov 7, 2011 Purpose We studied BCR-ABL1 transcript levels in patients with to express transcript results on the widely accepted international scale; thus,
Oct 10, 2015 The clinical decision to discontinue such therapy depends on the patient's molecular response (MR), derived from the international scale of BCR-
Jun 30, 2020 Keywords: CML; nilotinib; e13a2; e14a2; BCR-ABL1 results are aligned on the international scale by the 5 laboratories involved in our study. Mar 20, 2019 both e13a2 and e14a2 Major BCR-ABL1 transcripts and the reference target ABL1. The test results are provided in international scale (IS)
May 21, 2018 are detected by FDA approved QuantideX® qPCR BCR-ABL IS Kit and the result is calibrated and reported on the International Scale (%IS).
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measurements are related to a standardized baseline (Hughes et al, 2006). INTRODUCTION: Standardization of BCR-ABL1 messenger RNA quantification by real-time PCR on the International Scale (IS) is critical for monitoring therapy response in chronic myelogenous leukaemia. For almost 10 years, the main goal of the treatment of CML with tyrosine kinase inhibitors (TKIs) has been the achievement of the so-called “major molecular response” (MMR; BCR-ABL1 ≤ 0.1% on the International Scale) 2 (see figure). Then, the main focus shifted to the so-called “early molecular response” (EMR; BCR-ABL1 ≤ 10% at 3 months) as a predictor of a deeper response and of a identified. If positive, the quantitative level is reported as the normalized ratio of BCR/ABL1 (p210) to endogenous ABL1 mRNA with conversion to a percentage referenced to the international scale (IS), on which 0.1% BCR/ABL1:ABL1 (also represented on a log scale as Molecular Response 3, or MR3) is designated as a major BCR-ABL1, t(9;22) Source: 31208-2: 2005012: BCR-ABL1, Major (p210) Result: 42714-6: 2005014: BCR-ABL1, International Scale (Percent) 69380-4: 2005015: EER BCR-ABL1, Major (p210) 11526-1 What is the abbreviation for BCR-ABL1 ≤ 0.1% On The International Scale?
By using a WHO international standard panel estab-
Monitoring BCR-ABL1 expression levels relative to clinically validated response criteria on the International Scale (IS) is vital in the optimal management of patients with chronic myeloid leukemia, yet significant variability remains across laboratories worldwide.
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Steering Committee of Eighteen Months Storage and Analysis of Sensitive Large-Scale Biomedical .